Brock Purdy, Jauan Jennings, and Ricky Pearsall have been ruled out for the 49ers-Rams matchup, with the San Francisco 49ers facing a shorthanded schedule against the Jacksonville Jaguars on Thursday night. Quarterback Brock Purdy’s toe injury, which had previously sidelined him for two games, flared up after Sunday’s loss to the Jaguars. Mac Jones, the quarterback, is now set to start the game, marking his third start of the 2025 season. Jones’ performance highlights a strong streak of 66% completion and 563 yards with four touchdowns and an interception, as the 49ers won both games. While Jones has been dealing with a knee injury, he remains a full participant in all three recent reports and has no current game status. Jennings is recovering from ankle and rib issues, while Pearsall faces a knee injury. The injury reports this week were estimates, yet neither player would have played all three days. Receiver Jordan Watkins (calf) and defensive end Robert Beal (ankle) have also been ruled out. Defensive tackle C.J. West (thumb) is questionable, and cornerbacks Renardo Green (neck), Yetur Gross-Matos (knee), offensive tackle Colton McKivitz (calf), and defensive end Mykel Williams (wrist/oblique), as well as linebacker Dee Winters (knee), are off the list and set to play.
